Locus Specific Probe for BCL2 Gene 5' Region    

The BCL2 5’ FISH Probe is designed to detect the human BCL2 gene 5’-region located on chromosome band 18q21.33. BCL2 is also known as Bcl-2 or PPP1R50.

The BCL2 5' FISH probe is labeled with CytoOrange. CytoOrange is a fluorophore with an excitation peak at 551nm and emission peak at 575nm, giving it an orange fluorescent signal with the appropriate filters.

The BCL2 5' FISH probe hybridizes to chromosome 18 in both metaphase and interphase cells. After hybridizing with normal human peripheral blood lymphocyte samples, two distinct orange fluorescent spots are observed in the interphase nuclei, each spot corresponding to the 18q21.33 region on the chromosome 18. In metaphase cells, a “doublet” or “split signal” may appear on chromosomal region 18q21.33. Each signal within the doublet represents one of the two sister chromatids present in the replicated chromosome 18.

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Analyte Specific Reagent. Analytical and performance characteristics are not established.